Perfil de farmacorresistencia del mycobacterium tuberculosis en pacientes que ingresaron a retratamiento de los establecimientos de las redes de salud bonilla, bepeca y ventanilla, DIRESA Callao, 2006-2010

Abstract

Objective: To determine the profile of drug resistance in Mycobacterium tuberculosis retreatment patients admitted to the local health networks Bonilla, Bepeca and Ventanilla, DIRESA Callao, 2006-2010 Materials and Methods: The patients diagnosed with tuberculosis smear (+) and sensitivity to anti-TB drugs that entered re-treatment, sensitivity tests were performed at the National Institute of Health (NIH), were used frequencies of the variables set and used measures of central tendency and dispersion for qualitative variables. Results: The prevalence of drug resistance to one or more drugs was 29%, Multi-resistance was 21%. The overall frequency of isoniazid resistance was 97.34% (n = 404), 81.20% rifampicin (n = 337), streptomycin 46.41% (n = 188). Conclusions: In this study we found that there is a high prevalence of resistant TB in patients admitted to retreat establishments Bonilla, Bepeca and Ventanilla Health networks, , Callao being the most prevalent form of MDR-TB being the most commonly drug resistance genus monoresistencia in patients with isoniazid.

Objective: To determine the profile of drug resistance in Mycobacterium tuberculosis retreatment patients admitted to the local health networks Bonilla, Bepeca and Ventanilla, DIRESA Callao, 2006-2010 Materials and Methods: The patients diagnosed with tuberculosis smear (+) and sensitivity to anti-TB drugs that entered re-treatment, sensitivity tests were performed at the National Institute of Health (NIH), were used frequencies of the variables set and used measures of central tendency and dispersion for qualitative variables. Results: The prevalence of drug resistance to one or more drugs was 29%, Multi-resistance was 21%. The overall frequency of isoniazid resistance was 97.34% (n = 404), 81.20% rifampicin (n = 337), streptomycin 46.41% (n = 188). Conclusions: In this study we found that there is a high prevalence of resistant TB in patients admitted to retreat establishments Bonilla, Bepeca and Ventanilla Health networks, , Callao being the most prevalent form of MDR-TB being the most commonly drug resistance genus monoresistencia in patients with isoniazid.Objetivo: Determinar el Perfil de farmacorresistencia del Mycobacterium tuberculosis en pacientes que ingresaron a retratamiento de los establecimientos de las redes de Salud Bonilla, Bepeca y Ventanilla, DIRESA Callao, 2006-2010 Materiales y mtodos: Se tom a los pacientes con diagnóstico de tuberculosis frotis (+) y pruebas de sensibilidad a fármacos anti-tuberculosos que ingresaron a Re-Tratamiento, se realizaron pruebas de sensibilidad en el Instituto Nacional de Salud (INS), se utilizaron las frecuencias de las variables establecidas y se utilizaron las medidas de tendencia central y de dispersión en las variables cualitativas. Resultados: La prevalencia farmacorresistencia a uno o más fármacos fue de 29%, Multi-resistencia fue 21%. La frecuencia en general de resistencias fue isoniacida 97,34%(n=404), rifampicina 81,20%(n=337), estreptomicina 46,41%(n=188). Conclusiones: En el presente trabajo se encontró que existe una elevada prevalencia de TBC resistente en los pacientes que ingresaron a retratamiento de los establecimientos de las redes de Salud Bonilla, Bepeca y Ventanilla, DIRESA Callao siendo la forma la de mayor prevalencia la TBC-MDR, siendo el fármaco que con mayor frecuencia genero resistencia en los pacientes con monoresistencia la isoniacida.