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dc.contributor.authorCaro-Consuegra, Rocioes_PE
dc.contributor.authorNieves-Colón, Maria A.es_PE
dc.contributor.authorRawls, Erines_PE
dc.contributor.authorRubin-de-Celis, Verónicaes_PE
dc.contributor.authorLizárraga, Beatrizes_PE
dc.contributor.authorVidaurre, Tatianaes_PE
dc.contributor.authorSandoval, Karlaes_PE
dc.contributor.authorFejerman, Lauraes_PE
dc.contributor.authorStone, Anne C.es_PE
dc.contributor.authorMoreno-Estrada, Andréses_PE
dc.contributor.authorBosch, Elenaes_PE
dc.description.abstractPeru hosts extremely diverse ecosystems which can be broadly classified into the following three major ecoregions: the Pacific desert coast, the Andean highlands, and the Amazon rainforest. Since its initial peopling approximately 12,000 years ago, the populations inhabiting such ecoregions might have differentially adapted to their contrasting environmental pressures. Previous studies have described several candidate genes underlying adaptation to hypobaric hypoxia among Andean highlanders. However, the adaptive genetic diversity of coastal and rainforest populations has been less studied. Here, we gathered genome-wide single-nucleotide polymorphism-array data from 286 Peruvians living across the three ecoregions and analyzed signals of recent positive selection through population differentiation and haplotype-based selection scans. Among highland populations, we identify candidate genes related to cardiovascular function (TLL1, DUSP27, TBX5, PLXNA4, SGCD), to the Hypoxia-Inducible Factor pathway (TGFA, APIP), to skin pigmentation (MITF), as well as to glucose (GLIS3) and glycogen metabolism (PPP1R3C, GANC). In contrast, most signatures of adaptation in coastal and rainforest populations comprise candidate genes related to the immune system (including SIGLEC8, TRIM21, CD44, and ICAM1 in the coast; CBLB and PRDM1 in the rainforest; and BRD2, HLA-DOA, HLA-DPA1 regions in both), possibly as a result of strong pathogen-driven selection. This study identifies candidate genes related to human adaptation to the diverse environments of South America.es_PE
dc.publisherOxford Academices_PE
dc.sourceOxford Academices_PE
dc.subjectPeruvian populationses_PE
dc.subjecthigh-altitude adaptationes_PE
dc.subjecthuman adaptationes_PE
dc.titleUncovering Signals of Positive Selection in Peruvian Populations from Three Ecological Regionses_PE

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